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A high shear mixer granulator has a cylindrical mixing bowl, a chopper, and a motor that drives the mixing blades. The mixing bowl is jacketed(optional item for the special process) for insulating/cooling the elements of the bowl. But, the process of granulation can be split into various stages, namely:
- Powder mixing
- Granule attrition
- Breakage
- Powder wetting
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Top essential things to know about a high shear mixer granulator speed
1. How speed affects uses and applications of a high-shear granulator
A high-shear mixer granulator is used to generate suspensions and granular products. It’s also used in creating adhesives, food, chemical, and suspensions. The device consists of a conical mixing bowl, a chopper, and a motor. Like any other pharmaceutical equipment used in spheroid manufacturing, the machine plays an important role in the sector. Its impact is affected by the speed of the wet massing time. This has a direct impact on the size of the granules.
2. Recent developments of granulation and how speed affects results
Granulation is an essential unit operation. The powder particles are designed to form large agglomerates known as granules. This process helps to improve formulation operations by changing fine particles into dust-free blends. The distribution of these formulation ingredients can be compressed into smaller particles. With that said, granulation is more of an art.
There are a few measures that professionals in the industry can take to determine the final point of granulation. That is when the desired particle size is achieved. A straightforward method that operators may also use is creating a robust ball of granules using their hands. What remains after breaking the ball needs to be granular instead of resembling a fine powder. However, the results and the granulation process are affected by the speed of the granulating machine.
3. Factors affecting the operation of a granulator
The impeller of the high-shear granulation machine is employed when it comes to mixing dry powder as well as spreading the granulating fluid. It rotates speed according to your process requirements. As such, the chopper forms some part of the high-shear granulator, which is used to break down wet lumps in producing granules. Below are the main factors that affect the granulation process and its speed.
- Formulation variables – this is the volume of excipients utilized in the granulation process
- Physical properties of elements being granulated
- Process variables including the loading speed of the granulator bowl and the impeller speed
- Granulator design
4. Effect of the impeller speed on granules
Impeller speed is a critical element that affects the properties of the granules. Secondly, mechanical properties affect the performance of the machines. How the system of granulation responds to the transition in the speed of the impeller highly depends on the binder system being used. A binder with low viscosity decreases the size of granules produced. The opposite is true about a binder system with a high viscosity, it’s also related to humidity. High shear mixer granulator working principle is very important.
5. How the chopper speed affects the operation and results of a granulator
The operation of a granular is highly influenced by several factors, including the features of the feedstock, which is the initial starting point in any project of granulation. Feedstock has to meet specific parameters for granulation to occur successfully. Some vital characteristics are such as particle size distribution and moisture content. The chopper speed has a significant impact on the size of granules. It also allows for better distribution of granules in the machine.
6. Different granulators have different speed
Granulators come in various sizes as well as shapes created to granulate particles differently. Therefore, a granulator can be integrated into an extrusion system and grinding edge trim created to recycle particles. The trim of the edge is inserted into a nozzle and conveyed to a small granulator that chops the trim into small flakes. A granulator is not only designed with high speed, but medium inertia created to open the rotor body for excellent grinding. Diameter holes determine the size of the end products.
7. How speed affects the maintenance of a high-shear granulator
High shear mixer and granulator produce a wet mass when the high shear mixer granulator process is complete. The discharge is passed through a wet mill. The process facilitates downstream drying through a fluid bed dryer. However, the speed of the high-shear granulator affects its general operation and maintenance. Therefore, a high-speed shear granulator is easy to maintain and clean.
8. Granulation technologies are affected by the speed
There are several granulation technologies. Given the value of granulation when it comes to the manufacture of dosage forms, manufacturers are given insight based on different granulation technologies and their applications. The three most invaluable granulation processes used for solid dosage form manufacture are dry granulation, direct blending, coupled with wet granulation. The success of these processes depends on the speed of the granulator.
9. Salient Features and how they are impacted by speed
The total number of parts of a high shear granulator may vary depending on the type of machine. Being a professional, you should evaluate all machine parts to be sure that they meet the pharmaceutical requirements of your project, including specification demands. Some of the key elements include:
- High-speed mixing as well as granulating
- Four-arm mixing impeller coupled with a blade angle
- Fitting discharge plug
- High precision mixing machine
The characteristics of solid dosage forms depend on the process of granulation and the type of machine used. Choosing an appropriate granulation technique is crucial to the success of the project.
Scale-up of high shear mixer granulator discrete element analysis, lab high shear mixer granulator also influenced by the above factors.
Conclusion
When buying your high shear mixer granulator, there are several factors you need to check. However, within the long list of must-have qualities in your dream machine, high shear mixer granulator speed remains one of the most thought of factors. But as you choose your machine with speed and the most considered factor, bear in mind, other factors affect speed as well. It is your call to identify these factors that affect speed as specified above and how they will affect your machine performance.
If you need high shear mixer granulator, please don’t hesitate to contact Senieer right now.